Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients
Background: Glioblastoma (GBM) is the deadliest and most common brain tumor in adults, with poor survival and response to aggressive therapy.Limited peperomia double duty access of drugs to tumor cells is one reason for such grim clinical outcomes.A driving force for therapeutic delivery is interstitial fluid flow (IFF), both within the tumor and i